Department of Pathology
Research Seminar Series
You are invited to a Special Seminar on January 18, 2017 at 12:00 given by Jean Soonmyong Oak, MD, PhD, Stanford University, Department of Pathology.
The seminar is titled “Angioimmunoblastic T-Cell Lymphoma with Emphasis on Rare Lymphoplasmacytic and Plasma Cell Proliferations” and will be held at the 1104 Scaife Hall, 3550 Terrace Street
Nodal T cell neoplasms consists of a heterogeneous group of lymphoproliferative disorders that are diagnostically challenging due to morphologic and immunophenotypic overlap with reactive causes and non-T cell lymphoid neoplasms. A growing number of molecular and immunohistochemistry studies reveal that angioimmunoblastic T cell lymphoma (AITL) and a subset of peripheral T cell lymphoma, not otherwise specified, derive from follicular helper T cells (TFH) and are often associated a concurrent B cell proliferation. Despite the crucial role TFH cells plays in germinal center biology and plasma cell differentiation, monoclonal plasma cell or lymphoplasmacytic proliferations are rare in AITL and have not been systematically studied. In this lecture we will discuss the morphologic, immunophenotypic, and genetic features of AITL and review cases that show a concurrent monoclonal lymphoplasmacytic or plasma cell proliferations