David Boone, PhD

Controlled dimerization of insulin-like grown factor-1 and insulin receptors reveal shared and distinct activities of holo and hybrid receptors

Chen J, Nagle AM, Wang YF, Boone DN, Lee AV. Controlled dimerization of insulin-like grown factor-1 and insulin receptors reveal shared and distinct activities of holo and hybrid receptors. J Biol Chem. 2018 Jan 12. pii: jbc.M117.789503. doi: 10.1074/jbc.M117.789503. [Epub ahead of print]. PMID: 23990302.

Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer

Warburton AJ, Boone DN. Insights of Global Analyses of Long Noncoding RNAs in Breast Cancer. Curr Pathobiol Rep. 2017 Mar;5(1):23-34. doi: 10.1007/s40139-017-0122-1. Epub 2017 Jan 23. PubMed PMID: 28616363. PubMed Central PMCID: PMC5467540.

Computer Science, Biology and Biomedical Informatics academy: Outcomes from 5 years of Immersing High-school Students into Informatics Research

King AJ, Fisher AM, Becich MJ, Boone DN. Computer Science, Biology and Biomedical Informatics academy: Outcomes from 5 years of Immersing High-school Students into Informatics Research. J Pathol Inform. 2017 Feb 28;8:2. doi: 10.4103/2153-3539.201110. eCollection 2017. PMID: 28400991 PMC ID: 5359992.

Role for Histone H2B Variants in Endocrine Resistant Breast Cancer

Nayak S, Harrington E, Boone DN, Hartmaier R, Pathiraja, T, Cooper K, Fine J, Sanfilippo J, Davidson N, Lee AV, Dabbs D, and Oesterreich S. A Role for Histone H2B Variants in Endocrine Resistant Breast Cancer. Hormones and Cancer. 2015  PUBMED 26113056

Role of IGF1R in breast cancer subtypes, stemness, and lineage differentiation

Farabaugh SM, Boone DN, and Lee AV. Role of IGF1R in breast cancer subtypes, stemness, and lineage differentiation.  Frontiers in Endocrinology. 2015. PUBMED 25964777

Domain specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activitys

Zhang Q, Spears E, Boone DN, Li Z, Gregory M, and Hann S.  Domain specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activitys.  PNAS. 2012; 110(3):978-83. PUBMED 23277542

Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression Profiling

Boone DN and Lee AV. Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression Profiling. Critical Reviews in Oncogenesis.  2012;17(2):161-73. PUBMED 22471706

The Myc-ARF-Egr1 Pathway: Unleashing Myc’s Apoptotic Power

Boone DN and Hann SR. The Myc-ARF-Egr1 Pathway: Unleashing Myc’s Apoptotic Power.  Cell Cycle.  2011 Jul1;10(13):2043-4.  PMC3234342

Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.

Boone DN, Qi Y, Li Z, and Hann S. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. PNAS. 2011 Jan 11;108(2):632-7.  PUBMED 21187408

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.

Zhaoliang Li, Boone D, and Hann S.  Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.  PNAS.  2008 Dec 2;105(48):18794-9. PUBMED 19033198

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