Publications for Xinghua Lu, MD, PhD, MS

2017

Vicky Chen, John Paisley and  Xinghua Lu.  Revealing common disease mechanisms shared by tumors of different tissues of origin through semantic representation of genomic alterations and topic modeling.  BMC Genomics 2017 18(Suppl2):105. DOI: 10.1186/s12864-017-3494-z

2016

Lu, S., Mandava, G., Yan, G., and Lu, X (2016) An exact algorithm for finding cancer driver somatic genome alterations: the weighted mutually exclusive maximum set cover problem.  Algorithm for Molecular Biology 11:1, DOI: 10.1186/s13015-016-0073-9   PMCID: PMC4855522

Stolovitzky, G., Hill, S., Heiser, L, Lu, X, Jiang, X, et al.  (2016) Inferring causal molecular networks: empirical assessment through a community-based effort.  Nature Methods. 13, 310–318 PMID: 26901648 PMCID: PMC4854847

 

Chen, L., Cai, C., Chen, V., and Lu, X (2015) Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model.  BMC Bioinformatics Suppl 1:9. doi: 10.1186/s12859-015-0852-1. PMID: 26818848  PMCID: PMC4895523

S. Lu, C. Cai,  G. Yan,  Z. Zhou, Y. Wan, L. Chen, V. Chen, G. Cooper, L. Obeid, Y. Hannun, A. Lee and X. Lu. Signal-oriented pathway analyses reveal a signaling complex as a synthetic lethal target for p53 mutations, Cancer Research 2016, Minor revision

2015

Lujia Chen, Chunhui Cai, Vicky Chen and Xinghua Lu.  Trans-species learning of cellular signaling systems with bimodal deep belief networks.  Bioinformatics 2015;
doi: 10.1093/bioinformatics/btv315 

Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R, Center for Causal Discovery team. The Center for causal discovery of biomedical knowledge from Big Data. Journal of the American Medical Informatics Association 2015 Jul 2. pii: ocv059. doi: 10.1093/jamia/ocv059. [Epub ahead of print]  PMID: 26138794

Lu, S., Lu, KN, Cheng, S., Ma, X., Nystrom, N., Lu, X. (2015) Identifying driver genomic alterations in cancers by searching minimum-weight, mutually exclusive sets.  PLoS Computational Biology 11(8):e1004257 PMID: 26317392  PMCID: PMC4552843

Ogoe, HA, Visweswaran, S, Lu, X, Gopalakrishnan, V.  (2015) Knowledge transfer via classification rules using functional mapping for integrative modeling of gene expression data.  BMC Bioinformatics 16:226 (designated as a Highly Accessed paper) PMID: 26202217 PMCID: PMC4512094

2014

Cai C, Chen L, Jiang X, Lu X. Integrating protein phosphorylation and gene expression data to infer signaling pathways. Cancer Informatics Supplement on Cancer Clinical Information Systems. 2014; 13(s1): 59-67. doi: 10.4137/CIN.S13883

Jiang X, Cai B, Xue D, Lu X, Cooper GF, Neapolitan RE. A comparative analysis of methods for predicting clinical outcomes using high-dimensional genomic datasets. Journal of the American Medical Informatics Association (2014). Oct;21(e2):e312-9. doi: 10.1136/amiajnl-2013-002358. Epub 2014 Apr 15.  PMID: 24737607 PMC4173174

2013

Lu, S., and Lu, X (2013) Using graph model to find transcription factor modules: the hitting set problem and an exact algorithm. Algorithms for Molecular Biology 8:2 PMCID: PMC3622577

Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X. Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses.  Science Signaling 6(299), rs14. [DOI: 10.1126/scisignal.2004515] (2013)  PMID: 24170935 PMC3974757

Hatice Ulku Osmanbeyoglu, Kevin N. Lu, Steffi Oesterreich, Roger S. Day, Panayiotis V. Benos, Claudia Coronnello and Xinghua Lu. Estrogen represses gene expression through reconfiguring chromatin structures. Nucleic Acids Research, 2013, 1–11. doi:10.1093/nar/gkt586.
 

David J. Montefusco, Lujia Chen, Nabil Matmati, Songjian Lu, Benjamin Newcomb, Gregory F. Cooper, Yusuf A. Hannun, and Xinghua Lu.  Science Signaling, 6(299): p. rs14 [DOI: 10.1126/scisignal.2004515] http://stke.sciencemag.org/cgi/content/full/sigtrans;6/299/rs14

Zhao, Z., Shen, B., Lu, X., and Vongsangnak, W (2013) Translational Biomedical Informatics and Computational Systems Medicine. BioMed Research International, vol. 2013, Article ID 237465, 2013. doi:10.1155/2013/237465

Montefusco, D., Chen, L, Matmati, N., Lu, S., Newcomb, B., Cooper, GF., Hannun, YA., Lu, X., (2013) Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and integromics analyses. Science Signaling 6:rs14

Osmanbeyoglu, H, Lu, K., Oesterreich, S, Day, RS, Benos, PV, Coronnello, C., and, Lu, X (2013) Estrogen represses gene expression through chromatin reconfiguration. Nucleic Acid Research 41(17): 8061-8071

Chen, V and Lu, X (2013) Conceptualization of molecular findings by mining gene annotations. BMC Proceedings 7(Suppl 7):S2

Lu, S., Jin, B., Cowart, LA., and Lu, X (2013) From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data. PLoS One 8(4): e61134  PMID: 23637789 PMCID: PMC3634064

Mowrey, D., Cheng, M., Liu, L., Willenbring, D., Lu, X., Wymore, T., Xu, Y., and Tang, P.. (2013) Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels. J Am Chem Soc. 135(6):2172-80. PMCID: PMC3582375

2012

Lu, S. and Lu, X (2012) Integrating genome and functional genomics data to reveal perturbed signaling pathways in ovarian cancers. Proceedings of AMIA Summit on Translational Bioinformatics, San Francisco.

Qin, T., Tsoi, LC., Sims KJ, Lu, X and Zheng, WJ (2012) Signaling network prediction using the ontology fingerprint enhanced Bayesian networks. BMC Systems Biology 6 (Suppl 3) : S3 (co-corresponding author)

Richards, A., Schwacke, J., Rohrer, B., Cowart, LA. and Lu, X (2012) Revealing functionally coherent gene subset using spectral clustering and information integration approaches. BMC Systems Biology 6 (Suppl 3) : S7

Osmanbeyoglu, H, Hartmaier, R., Oesterreich, S., and Lu, X. (2012) Improving ChIP-seq peak-calling for functional indirect co-regulator binding by integrating multiple sources of biological information. BMC Genomics 13(Suppl 1):S1

Feng, H, Hu, B, Liu, KW, Lu, X, Yiin, JJ, Lu, S, Keezer, S, Fenton, T, Furnari, FB, Hamilton, RL, Vuori, K, Nagane, M, Nishikawa, R, Cavenee, WK and Cheng, SY (2012) Aberrant Activation of Rac1 by Src-dependent Phosphorylation of Dock180Y1811 Mediates PDGFRα-stimulated Glioma Growth and Invasion. Journal of Clinical Investigation 121(12):4670–4684

2011

Jin, B., Chen, V., Chen, L., and Lu, X. (2011) Mapping annotations with textual evidence using an scLDA model. Proceedings of AMIA Annual Symposium, Washington DC

Lu, S and Lu, X (2011). A graph model and an exact algorithm for finding cooperative transcription factor modules. Proceedings of ACM Bioinformatics and Computational Biology 2011

2010

Jin, B. and Lu, X (2010). Identifying informative subsets of the Gene Ontology with information bottleneck methods. Bioinformatics 26 (19): 2445-2451

Cowart, LA., Shotwell, M., Worley, ML.,  Richards, AJ, Montefusco, DJ, Hannun YA, and Lu, X. (2010) Revealing a signaling role of PHS1P in yeast using integrative systems approaches.  Molecular Systems Biology 6:349 PMID: 20160710(Selected for presentation at the Highlight Track of ISMB 2010 as a major advance in the field)

Richards*, AJ, Muller, B., Shotwell, M, Cowart, LA, Rohrer, B, and Lu, X (2010) Assessing the functional coherence of gene sets with metrics based on the Gene Ontology graph.  Bioinformatics, supplement issue for the Proceedings for the Intelligent Systems in Molecular Biology (ISMB) 2010 (19% acceptance) PMID: 20529941

Cowart, LA., Shotwell, M., Worley, ML.,  Richards, AJ, Montefusco, DJ, Hannun YA, and Lu, X.. (2010) Revealing a signaling role of PHS1P in yeast using integrative systems approaches.  Molecular Systems Biology 6:349 PMID: 20160710(Selected for presentation at the Highlight Track of ISMB 2010 as a major advance in the field)

2009

Zheng*, B. and Lu, X (2009) Application of semantic modeling in bioinformatics domain.  In: Data Management in Semantic Web, Ed. Jin, H. and Lv, Z,.  Nova Science Publishers, Inc.

Jin*, B and Lu, X (2009) Enhancing GO-graph-based multi-label classification using semantic-rich GO terms.   Proceedings of the Annual Meeting of the ISMB BioLINK Workshop 2009

Muller*, B., Richards, AJ., Jin, B., Lu, X. (2009) GOGrapher; A Python library for GO graph representation and analysis.  BMC Research Notes 2:122 PMID:19583843

Kozel, FA.,  Johnson, KA., Grenesko,EL., Laken, SJ., Kose, S, Lu, X., Pollina, D., Ryan, A and George, MS (2009) Functional MRI detection of deception after committing a mock sabotage crime.  J. Forensic Sciences, 54(1):220-31. PMID: 19067772

Jin*, B., Strasburger, A., Laken, SJ., Kozel, FA., Johnson, KA., George, MS., and Lu, X. (2009) Feature selection for fMRI-based deception detection.  BMC Bioinformatics 10 (Suppl 9):S15 (Outstanding Paper Award at the AMIA Summit on Translational Bioinformatics) PMID: 19761569

Muller*, B., Richards, AJ., Jin, B., Lu, X. (2009) GOGrapher; A Python library for GO graph representation and analysis.  BMC Research Notes 2:122 PMID:19583843

Jin*, B and Lu, X (2009) Enhancing GO-graph-based multi-label classification using semantic-rich GO terms.   Proceedings of the Annual Meeting of the ISMB BioLINK Workshop 2009

2008

Jin, B*., Muller*, B., Zhai, CX, and Lu, X (2008) Multi-label literature classification based on the Gene Ontology graph.  BMC Bioinformatics 9:525. PMID: 19063730

2007

Chen, Y., Zheng*, B., Robbins, DH.,  Lewin, DN., Mikhitarian, K, Graham, A., Rumpp, L, Glenn, T, Gillanders, WE, Cole, DJ,  Lu, X, Hoffman, BJ. and Michael Mitas (2007) Accurate discrimination of pancreatic ductal adenocarcinoma and chronic focal pancreatitis using multi-marker expression data and samples obtained by minimally invasive fine needle aspiration. International Journal of Cancer, 120(7):1511. PMID: 17192896

Zheng*, B., and Lu, X. (2007)  Novel metrics for evaluating the functional coherence of protein groups via protein-semantic-network. Genome Biology 8:R153     [doi:10.1186/gb-2007-8-7-r153] PMID: 17672896

2006

Cowart, L.A., Okamoto, Y., Lu, X. and Hannun, Y.A. (2006) Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae.  Biochemical J.  393(3):733. PMID: 16201964

Zheng*, B., McLean*, DC., and Lu, X. (2006) Identifying biological concepts from a protein-related corpus with a probabilistic topic model. BMC Bioinformatics 7:58. PMID: 16466569

Chen*, Y.A., Chou, C.C., Lu, X., Slate, E.H., Peck, K., Xu, W., Voit, E.O., and Almeida, J.S. A  (2006) Multivariate prediction model for microarray cross-hybridization.  BMC Bioinformatics 7:101 (Designated as highly accessed paper)  PMID: 16509965

Lu, X., Zheng*, B., Velivelli, A. and  Zhai, C (2006) Enhancing text categorization with semantic-enriched representation and training data augmentation.  J Am Med Inform Assoc, 13(5):526-35. PMID: 16799127

2004

Lu, X., Zhai, C., Gopalakrishnan, V.,and Buchanan, B.G. (2004) Automatic annotation of protein motif function with Gene Ontology terms.  BMC Bioinformatics 5:122. PMID: 15345032

Tao, T., Zhai, C., Lu, X. and Fang, H. (2004) A study of statistical methods for predicting function of protein motifs. Applied Bioinformatics, 3:115-124.  PMID: 15693737

2003

Lu, X., Ellis-Davies, G.C.R., and Levitan E.S.(2003) Calcium requirements do not delimit the releasable neuropeptide pool. Cell Calcium 33(4):267-271. PMID: 12618147

Ng, Y.K., Lu, X., Gulacsi, A., Han, W., Saxton, M.J. and Levitan, E.S. (2003) Unexpected mobility variation among individual secretory vesicles produces an apparent refractory neuropeptide pool. Biophysical J. 84(6):4127-34. PMID: 12770915

2002

Ng, K., Lu, X., Levitan, ES.. (2002)  Physical mobilization of secretory vesicles facilitates neuropeptide release by nerve growth factor-differentiated PC12 cells.  J Physiol (London) 542 (Pt2) 395-402. PMID: 12122140

Ng, Y.K., Lu, X. (equal contributing author), Walkins, S.C., Ellis-Davies, G.C. and Levitan, E.S., (2002) Nerve growth factor-induced differentiation changes the cellular organization of regulated peptide release by PC12 cells.  J. Neurosci. 22(10):3890-7. PMID: 12019308

2000

Laplante JM, O'rourke F, Lu, X, Fein A, Olsen A, Feinstein MB  (2000) Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of  antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and  decreases cell  proliferation. Biochem. J.  348:189-99. PMID: 10794731

Zhang, T., Gealy, R., Lu, X., Takimoto, K., and Levitan, ES., (2000)  TRH regulates Kv1.5 gene expression though a Galphaq-mediated PLC-independent pathway.  Mol. Cell Endocrinol. 25;165(1-2):33-39. PMID: 10940481

1999

Signore, A., O’Rourke, F., Lu, X., Feinstein, and Yeh, H. (1999)  Immunohistochemical localization of the InsP4 Receptor GTPase-Activating Protein GAP1IP4BP in the rat Brain.   J. Neurosci. Res. 55:321-328. PMID: 10348663

1998

Lu, X., Fein, A., Feinstein, M.B. and O’Rourke, F.A.,  (1999)  Antisense knock out of the Inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in the human erythroleukemia cell line leads to the appearance of intermediate conductance K(Ca) channels that hyperpolarize the membrane and enhance calcium influx.  J. Gen. Physiol.  113:81-9

Cai, C., Chen, L., Jiang, X., and Lu, X., (2014) Integrating protein phosphorylation and gene expression data to infer signaling pathways. Cancer Informatics, in press
^