Publications for Xinghua Lu, MD, PhD, MS

2018

Sadahiro H, Kang K, Gibson J, Minata M, Yu H, Shi J, Chhipa R, Chen Z, Lu S, Simoni Y, Furuta T, Sabit H, Zhang S, Bastola S, Yamaguchi S, Alsheikh H, Komarova S, Wang J, Kim S, Hambardzumyan D, Lu X, Newell E, Dasgupta B, Nakada M, Lee L, Nabors B, Norian L, Nakano I. Activation of the receptor tyrosine kinase AXL mediates the immune microenvironment in glioblastoma. Cancer Res. 2018; in press.

2017

Watters RJ, Hartmaier RJ, Osmanbeyoglu HU, Gillihan RM, Rae JM, Liao L, Chen K, Li W, Lu X, Oesterreich S. Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen. Mol Cell Endocrinol. 2017 Jun 15; 448:21-27. doi: 10.1016/j.mce.2017.03.005. Epub 2017 Mar 7. PMID: 28286232. 

Yan G, Chen V, Lu X, Lu S. A signal-based method for finding driver modules of breast cancer metastasis to the lung. Sci Rep. 2017 Aug 30; 7(1):10023. doi: 10.1038/s41598-09951-2. PMID: 28855549. PMC ID: PMC5577160.

Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):840-855.e8. doi: 10.1016/j.ccell.2017.11.005. PMID: 29232556. 

Ding MQ, Chen L, Cooper GF, Young JD, Lu X. Precision Oncology Beyond Targeted Therapy: Combining Omics Data with Machine Learning Matches the Majority of Cancer Cells to Effective Therapeutics. Mol Cancer Res. 2017 Nov 13. pii: molcanres.0378.2017. doi: 10.1158/1541-7786.MCR-17-0378. [Epub ahead of print] PMID: 29133589

Young JD, Cai C, Lu X. Unsupervised deep learning reveals prognostically relevant subtypes of glioblastoma. BMC Bioinformatics. 2017 Oct 3;18(Suppl 11): 381. doi: 10.1186/s12859-017-1798-2. PMID: 28984190. PMCID: PMC5629551. 

Chen V, Paisley J, Lu X. Revealing common disease mechanisms shared by tumors of different tissues of origin through semantic representation of genomic alterations and topic modeling. BMC Genomics. 2017 Mar 14;18 (Suppl 2):105. doi: 10.1186/s12864-017-3494-z. PMID: 28361690. PMC ID: PMC5374647.

2016

Huang T, Alvarez AA, Pangeni RP, Horbinski CM, Lu S, Kim SH, James CD, J Raizer J, A Kessler J, Brenann CW, Sulman EP, Finocchiaro G, Tan M, Nishikawa R, Lu X, Nakano I, Hu B, Cheng SY. A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Nat Commun. 2016 Oct 4;7:12885. doi: 10.1038/ncomms12885. PMID: 27698350. PMCID: PMC5059456.

Lu S, Mandava G, Yan G, and Lu X. An exact algorithm for finding cancer driver somatic genome alterations: the weighted mutually exclusive maximum set cover problem. Algorithms Mol Biol. 2016 May 4;11:11. doi: 10.1186/s13015-016-0073-9. PMID: 27148394. PMCID: PMC4855522.

Chen, L., Cai, C., Chen, V., and Lu, X (2015) Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model.  BMC Bioinformatics Suppl 1:9. doi: 10.1186/s12859-015-0852-1. PMID: 26818848  PMCID: PMC4895523

Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X. Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. Cancer Res. 206 Dec 1:76(23):6785-6794. doi: 10.1158/0008-5472.CAN-16-1740. Epub 2016 Oct 10. PMID: 27758891. PMCID: PMC5165695.

2015

Lujia Chen, Chunhui Cai, Vicky Chen and Xinghua Lu.  Trans-species learning of cellular signaling systems with bimodal deep belief networks.  Bioinformatics 2015;
doi: 10.1093/bioinformatics/btv315 

Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R, Center for Causal Discovery team. The Center for causal discovery of biomedical knowledge from Big Data. J Am Med Inform Assoc. 2015 Nov;22(6): 1132-6. doi: 10.1093/jamia/ocv059. Epub 2015 Jul 2.  PMID: 26138794. PMCID: PMC5009908.

Lu S, Lu KN, Cheng SY, Hu B, Ma X, Nystrom N, Lu X. Identifying driver genomic alterations in cancers by searching minimum-weight, mutually exclusive sets. PLoS Comput Biol. 2015 Aug 28; 11(8):e1004257. doi: 10.1371/journal.pcbi.1004257. eCollection 2015 Aug. PMID:26317392. PMCID: PMC4552843.

Ogoe, HA, Visweswaran, S, Lu, X, Gopalakrishnan, V.  (2015) Knowledge transfer via classification rules using functional mapping for integrative modeling of gene expression data.  BMC Bioinformatics 16:226 (designated as a Highly Accessed paper) PMID: 26202217 PMCID: PMC4512094

2014

Jiang X, Cai B, Xue D, Lu X, Cooper GF, Neapolitan RE. A comparative analysis of methods for predicting clinical outcomes using high-dimensional genomic datasets. Journal of the American Medical Informatics Association (2014). Oct;21(e2):e312-9. doi: 10.1136/amiajnl-2013-002358. Epub 2014 Apr 15. PMID: 24737607. PMC4173174.

Cai C, Chen L, Jiang X, Lu X. Integrating protein phosphorylation and gene expression data to infer signaling pathways. Cancer Informatics Supplement on Cancer Clinical Information Systems. 2014; 13(s1): 59-67. doi: 10.4137/CIN.S13883

2013

Zhao, Z., Shen, B., Lu, X., and Vongsangnak, W (2013) Translational Biomedical Informatics and Computational Systems Medicine. BioMed Research International, vol. 2013, Article ID 237465, 2013. doi:10.1155/2013/237465

Chen, V and Lu, X (2013) Conceptualization of molecular findings by mining gene annotations. BMC Proceedings 7(Suppl 7):S2

Lu S, Jin B, Cowart LA. Lu X. From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data. PLoS One. 2013 Apr 23;8(4):e61134. doi: 10.1371/journal.pone.0061134. Print 2013. PMID: 23637789. PMCID: PMC3634064.

Mowrey, D., Cheng, M., Liu, L., Willenbring, D., Lu, X., Wymore, T., Xu, Y., and Tang, P.. (2013) Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels. J Am Chem Soc. 135(6):2172-80. PMCID: PMC3582375

Lu S, Lu X. Using graph models to find transcription factor modules: the hitting set problem and an exact algorithm. Algorithms Mol Biol. 2013 Jan 16;8(1):2. doi: 10.1186/1748-7188-8-2. PMID: 23324335. PMCID: PMC3622577.

Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X. Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Sci Signal. 2013 Oct 29;6(299): rs14. doi: 10.1126/scisignal.2004515. PMID: 24170935. PMC3974757.

Osmanbeyoglu HU, Lu KN, Oesterreich S, Day RS, Benos PV, Coronnello C, Lu X. Estrogen represses gene expression through reconfiguring chromatin structures. Nucleic Acids Research, 2013, 1–11. doi:10.1093/nar/gkt586.

2012

Lu S, Lu, X. Integrating genome and functional genomics data to reveal perturbed signaling pathways in ovarian cancers. 2012 AMIA Jt Summits Transl Sci Proc. 2012;2012:72-8. Epub 2012 Mar 19. PMID: 22779056. PMCID: PMC3392049.

Qin, T., Tsoi, LC., Sims KJ, Lu, X and Zheng, WJ (2012) Signaling network prediction using the ontology fingerprint enhanced Bayesian networks. BMC Systems Biology 6 (Suppl 3) : S3 (co-corresponding author)

Richards, A., Schwacke, J., Rohrer, B., Cowart, LA. and Lu, X (2012) Revealing functionally coherent gene subset using spectral clustering and information integration approaches. BMC Systems Biology 6 (Suppl 3) : S7

Osmanbeyoglu, H, Hartmaier, R., Oesterreich, S., and Lu, X. (2012) Improving ChIP-seq peak-calling for functional indirect co-regulator binding by integrating multiple sources of biological information. BMC Genomics 13(Suppl 1):S1

Feng, H, Hu, B, Liu, KW, Lu, X, Yiin, JJ, Lu, S, Keezer, S, Fenton, T, Furnari, FB, Hamilton, RL, Vuori, K, Nagane, M, Nishikawa, R, Cavenee, WK and Cheng, SY (2012) Aberrant Activation of Rac1 by Src-dependent Phosphorylation of Dock180Y1811 Mediates PDGFRα-stimulated Glioma Growth and Invasion. Journal of Clinical Investigation 121(12):4670–4684

Lu S, Lu X. A graph model and an exact algorithm for finding cooperative transcription factor modules. Proc. 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine. 2012 Jul 31-Aug 3; 355-359.

2011

Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY. Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest. 2011 Dec;121(12):4670-84. doi: 10.1172/JCI58559. Epub 2011 Nov 14. PMID: 22080864. PMCID: PMC3223070.

Jin, B., Chen, V., Chen, L., and Lu, X. (2011) Mapping annotations with textual evidence using an scLDA model. Proceedings of AMIA Annual Symposium, Washington DC

2010

Jin, B. and Lu, X (2010). Identifying informative subsets of the Gene Ontology with information bottleneck methods. Bioinformatics 26 (19): 2445-2451

Cowart, LA., Shotwell, M., Worley, ML.,  Richards, AJ, Montefusco, DJ, Hannun YA, and Lu, X. (2010) Revealing a signaling role of PHS1P in yeast using integrative systems approaches.  Molecular Systems Biology 6:349 PMID: 20160710(Selected for presentation at the Highlight Track of ISMB 2010 as a major advance in the field)

Richards*, AJ, Muller, B., Shotwell, M, Cowart, LA, Rohrer, B, and Lu, X (2010) Assessing the functional coherence of gene sets with metrics based on the Gene Ontology graph.  Bioinformatics, supplement issue for the Proceedings for the Intelligent Systems in Molecular Biology (ISMB) 2010 (19% acceptance) PMID: 20529941

2009

Zheng*, B. and Lu, X (2009) Application of semantic modeling in bioinformatics domain.  In: Data Management in Semantic Web, Ed. Jin, H. and Lv, Z,.  Nova Science Publishers, Inc.

Muller*, B., Richards, AJ., Jin, B., Lu, X. (2009) GOGrapher; A Python library for GO graph representation and analysis.  BMC Research Notes 2:122 PMID:19583843

Kozel, FA.,  Johnson, KA., Grenesko,EL., Laken, SJ., Kose, S, Lu, X., Pollina, D., Ryan, A and George, MS (2009) Functional MRI detection of deception after committing a mock sabotage crime.  J. Forensic Sciences, 54(1):220-31. PMID: 19067772

Jin*, B., Strasburger, A., Laken, SJ., Kozel, FA., Johnson, KA., George, MS., and Lu, X. (2009) Feature selection for fMRI-based deception detection.  BMC Bioinformatics 10 (Suppl 9):S15 (Outstanding Paper Award at the AMIA Summit on Translational Bioinformatics) PMID: 19761569

Jin*, B and Lu, X (2009) Enhancing GO-graph-based multi-label classification using semantic-rich GO terms.   Proceedings of the Annual Meeting of the ISMB BioLINK Workshop 2009

2008

Jin, B*., Muller*, B., Zhai, CX, and Lu, X (2008) Multi-label literature classification based on the Gene Ontology graph.  BMC Bioinformatics 9:525. PMID: 19063730

2007

Chen, Y., Zheng*, B., Robbins, DH.,  Lewin, DN., Mikhitarian, K, Graham, A., Rumpp, L, Glenn, T, Gillanders, WE, Cole, DJ,  Lu, X, Hoffman, BJ. and Michael Mitas (2007) Accurate discrimination of pancreatic ductal adenocarcinoma and chronic focal pancreatitis using multi-marker expression data and samples obtained by minimally invasive fine needle aspiration. International Journal of Cancer, 120(7):1511. PMID: 17192896

Zheng*, B., and Lu, X. (2007)  Novel metrics for evaluating the functional coherence of protein groups via protein-semantic-network. Genome Biology 8:R153     [doi:10.1186/gb-2007-8-7-r153] PMID: 17672896

2006

Cowart, L.A., Okamoto, Y., Lu, X. and Hannun, Y.A. (2006) Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae.  Biochemical J.  393(3):733. PMID: 16201964

Zheng*, B., McLean*, DC., and Lu, X. (2006) Identifying biological concepts from a protein-related corpus with a probabilistic topic model. BMC Bioinformatics 7:58. PMID: 16466569

Chen*, Y.A., Chou, C.C., Lu, X., Slate, E.H., Peck, K., Xu, W., Voit, E.O., and Almeida, J.S. A  (2006) Multivariate prediction model for microarray cross-hybridization.  BMC Bioinformatics 7:101 (Designated as highly accessed paper)  PMID: 16509965

Lu, X., Zheng*, B., Velivelli, A. and  Zhai, C (2006) Enhancing text categorization with semantic-enriched representation and training data augmentation.  J Am Med Inform Assoc, 13(5):526-35. PMID: 16799127

2004

Lu, X., Zhai, C., Gopalakrishnan, V.,and Buchanan, B.G. (2004) Automatic annotation of protein motif function with Gene Ontology terms.  BMC Bioinformatics 5:122. PMID: 15345032

Tao, T., Zhai, C., Lu, X. and Fang, H. (2004) A study of statistical methods for predicting function of protein motifs. Applied Bioinformatics, 3:115-124.  PMID: 15693737

2003

Lu, X., Ellis-Davies, G.C.R., and Levitan E.S.(2003) Calcium requirements do not delimit the releasable neuropeptide pool. Cell Calcium 33(4):267-271. PMID: 12618147

Ng, Y.K., Lu, X., Gulacsi, A., Han, W., Saxton, M.J. and Levitan, E.S. (2003) Unexpected mobility variation among individual secretory vesicles produces an apparent refractory neuropeptide pool. Biophysical J. 84(6):4127-34. PMID: 12770915

2002

Ng K, Lu X, Levitan ES. (2002)  Physical mobilization of secretory vesicles facilitates neuropeptide release by nerve growth factor-differentiated PC12 cells.  J Physiol (London) 542 (Pt2) 395-402. PMID: 12122140

Ng YK, Lu X, Walkins SC, Ellis-Davies GC, Levitan ES. (2002) Nerve growth factor-induced differentiation changes the cellular organization of regulated peptide release by PC12 cells.  J. Neurosci. 22(10):3890-7. PMID: 12019308

2000

Laplante JM, O'rourke F, Lu, X, Fein A, Olsen A, Feinstein MB  (2000) Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of  antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and  decreases cell  proliferation. Biochem. J.  348:189-99. PMID: 10794731

Zhang T, Gealy R, Lu X, Takimoto K, Levitan ES. (2000)  TRH regulates Kv1.5 gene expression though a Galphaq-mediated PLC-independent pathway.  Mol. Cell Endocrinol. 25;165(1-2):33-39. PMID: 10940481

1999

Signore A, O’Rourke F, Lu X, Feinstein, Yeh H. (1999)  Immunohistochemical localization of the InsP4 Receptor GTPase-Activating Protein GAP1IP4BP in the rat Brain.   J. Neurosci. Res. 55:321-328. PMID: 10348663

1998

Lu X, Fein A, Feinstein MB, O’Rourke FA. (1999) Antisense knock out of the Inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in the human erythroleukemia cell line leads to the appearance of intermediate conductance K(Ca) channels that hyperpolarize the membrane and enhance calcium influx.  J. Gen. Physiol.  113:81-9

Cai C, Chen L, Jiang X, Lu X. (2014) Integrating protein phosphorylation and gene expression data to infer signaling pathways. Cancer Informatics, in press
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